G1044

Monoclonal Anti-Granzyme B antibody produced in mouse

clone GrB7, tissue culture supernatant

• Synonym(e): Anti-C11, Anti-CCPI, Anti-CGL-1, Anti-CGL1, Anti-CSP-B, Anti-CSPB, Anti-CTLA1, Anti-CTSGL1, Anti-HLP
• MDL-Nummer: MFCD01865484
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: tissue culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: GrB7, monoclonal
• Beschreibung: not suitable for immunocytochemistry (frozen sections)
• Mol-Gew.: antigen 33 kDa
• Speziesreaktivität: human
• Methode(n): immunocytochemistry: 1:20 using pretreated tissues; western blot: suitable
• UniProt-Hinterlegungsnummer: P10144
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... GZMB(3002)

Beschreibung

Spezifität

Does not cross-react with granzyme A.

Immunogen

recombinant human granzyme B.

Anwendung

Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.

Biochem./physiol. Wirkung

Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI). It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspases in vitro and in vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways. It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.

Physikalische Form

Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable