F8257

Flunarizin -dihydrochlorid

≥98% (TLC)

• Synonym(e): 1-[Bis-(4-fluorphenyl)-methyl]-4-(3-phenyl-2-propenyl)-piperazin -dihydrochlorid
• Empirische Formel (Hill-System): C₂₆H₂₆F₂N₂ · 2HCl
• CAS-Nummer: 30484-77-6
• Molekulargewicht: 477.42
• Beilstein: 4284243
• EG-Nummer: 250-216-6
• MDL-Nummer: MFCD00058198
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277835
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (TLC)
• Ersteller: Johnson & Johnson
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
• InChI: 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
• InChIKey: RXKMOPXNWTYEHI-RDRKJGRWSA-N

Beschreibung

Allgemeine Beschreibung

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Anwendung

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Biochem./physiol. Wirkung

Blocks T-type Ca²⁺/Na⁺ channels; inhibits K⁺-induced catecholamine release from chromaffin cells

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves