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F3422

Sigma-Aldrich

Flt-3/Flk-2 ligand human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)

Synonym(e):

FL

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About This Item

MDL-Nummer:
MFCD01093789
UNSPSC-Code:
51111800
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE and HPLC)

Form

lyophilized powder

Wirksamkeit

≤1.0 ng/mL

Mol-Gew.

17.6 kDa

Verpackung

pkg of 5 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P36888

Lagertemp.

−20°C

Angaben zum Gen

human ... FLT3(2322)

Allgemeine Beschreibung

Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.

Biochem./physiol. Wirkung

Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.

Physikalische Form

Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.

Hinweis zur Analyse

The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
S D Lyman et al.
Oncogene, 8(4), 815-822 (1993-04-01)
We have developed rabbit polyclonal antibodies to the C-terminus of the flt3-encoded protein, which is a member of the receptor tyrosine kinase family. Immunoprecipitation using this antiserum brings down two protein bands, a major band of 143 kDa and a
O Rosnet et al.
Oncogene, 6(9), 1641-1650 (1991-09-01)
Receptor-type tyrosine kinases presenting an extracellular region with five immunoglobulin-like domains, and strongly related by sequence similarities in the intracellular region, constitute a family of receptors involved in development and function of various cell lineages. We have isolated and characterized
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Artikel

Hematopoietic Cytokines

Read article on hematopoietic cytokines and hematopoiesis

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