F3393

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

fractionated antiserum, lyophilized powder

• Synonym(e): Anti-FGF2, Anti-bFGF
• MDL-Nummer: MFCD01322020
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: fractionated antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: human, bovine, rat
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1:1,000
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: P09038
• Anwendung(en): research pathology
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: bovine ... FGF2(281161) ; human ... FGF2(2247) ; rat ... Fgf2(54250)

Beschreibung

Allgemeine Beschreibung

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Immunogen

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Anwendung

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:

• immunohistochemistry
• immunostaining
• immunoblotting

Biochem./physiol. Wirkung

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Hinweis zur Analyse

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)