F112

(+)-Fenfluramine hydrochloride

• Synonym(e): (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride
• Empirische Formel (Hill-System): C₁₂H₁₆F₃N · HCl
• CAS-Nummer: 3239-45-0
• Molekulargewicht: 267.72
• EG-Nummer: 221-806-0
• MDL-Nummer: MFCD00069276
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24894746
• NACRES: NA.77

Eigenschaften

• Form: powder
• Arzneimittelkontrolle: USDEA Schedule IV
• Farbe: white to off-white
• Löslichkeit: H₂O: soluble 10 mg/mL
• Anwendung(en): forensics and toxicology
• Lagertemp.: room temp
• SMILES String: Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F
• InChI: 1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1
• InChIKey: ZXKXJHAOUFHNAS-FVGYRXGTSA-N
• Angaben zum Gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR6(3362) , HTR7(3363)

Beschreibung

Biochem./physiol. Wirkung

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

Sonstige Hinweise

Active isomer

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311 + H331
• P-Sätze: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges