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D9071

Sigma-Aldrich

Donitriptan monohydrochloride

≥98% (HPLC)

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About This Item

Empirische Formel (Hill-System):
C23H25N5O2 · HCl
CAS-Nummer:
170911-68-9
Molekulargewicht:
439.94
MDL-Nummer:
MFCD09027358
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329798891
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

white to off-white

Löslichkeit

H2O: >20 mg/mL

Lagertemp.

2-8°C

SMILES String

Cl.NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c4ccc(cc4)C#N)cc12

InChI

1S/C23H25N5O2.ClH/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19;/h1-6,13,15,26H,7-12,16,24H2;1H

InChIKey

ZXENQGQAPOYDOJ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Donitriptan is a potent, selective 5-HT1B/1D agonist.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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B Tom et al.
Cephalalgia : an international journal of headache, 22(1), 37-47 (2002-05-08)
We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.16-100 microg kg(-1), i.v.) dose-dependently decreased total carotid blood flow and vascular conductance
Rémon W M van den Broek et al.
European journal of pharmacology, 443(1-3), 125-132 (2002-06-05)
Donitriptan is a potent, high efficacy agonist at 5-HT(1B/1D) receptors. We investigated the contractile effects of donitriptan and sumatriptan on human isolated blood vessels of relevance to therapeutic efficacy in migraine (middle meningeal artery) and coronary adverse events (coronary artery).
Robert Letienne et al.
The Journal of pharmacology and experimental therapeutics, 305(2), 749-754 (2003-02-28)
The effects of donitriptan on systemic arterial-jugular venous oxygen saturation difference were evaluated in pentobarbitone-anesthetized pigs. Oxygen and carbon dioxide partial pressures in systemic arterial and jugular venous blood as well as hemoglobin oxygen saturation were determined by conventional blood
Robert Létienne et al.
The Journal of pharmacology and experimental therapeutics, 315(2), 849-857 (2005-07-20)
The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds cannot discriminate whether the decrease of
V Limmroth et al.
Pain, 92(1-2), 101-106 (2001-04-27)
Calcitonin gene related peptide (CGRP) released from the C-fibers projecting from the trigeminal ganglion to the meninges has been suggested to play a crucial role in the pathophysiology of headache, particularly migraine. In humans it has been shown that CGRP
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