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D7441

Sigma-Aldrich

Daltroban

>98% (HPLC)

Synonym(e):

4-{2-[(4-Chlorphenylsulfonyl)-amino]-ethyl}-phenylessigsäure, BM-13505, SKF-96148

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About This Item

Empirische Formel (Hill-System):
C16H16ClNO4S
CAS-Nummer:
79094-20-5
Molekulargewicht:
353.82
MDL-Nummer:
MFCD00868295
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724468
NACRES:
NA.77

Assay

>98% (HPLC)

Form

solid

Farbe

white

mp (Schmelzpunkt)

132.5-137.4 °C (lit.)

Löslichkeit

DMSO: soluble 22 mg/mL

SMILES String

OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

InChI

1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

InChIKey

IULOBWFWYDMECP-UHFFFAOYSA-N

Angaben zum Gen

human ... TBXA2R(6915)

Allgemeine Beschreibung

Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.

Biochem./physiol. Wirkung

Selektives Thromboxan A2-Rezeptor-Antagonist

Leistungsmerkmale und Vorteile

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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M Rathaus et al.
Clinical science (London, England : 1979), 88(6), 623-627 (1995-06-01)
1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase in the glomerular thromboxane B2-prostaglandin E2 ratio. 2. To
Sabine Pestel et al.
Biochemical pharmacology, 66(4), 643-652 (2003-08-09)
Prostanoids, i.e. prostaglandins and thromboxane, regulate liver-specific functions both in homeostasis and during defense reactions. For example, prostanoids are released from Kupffer cells, the resident liver macrophages, in response to the inflammatory mediator anaphylatoxin C5a, and mediate an enhanced glucose
U Sibelius et al.
Circulation, 101(1), 78-85 (2000-01-05)
Cardiac performance is severely depressed in septic shock. Endotoxin has been implicated as the causative agent in Gram-negative sepsis, but similar abnormalities are encountered in Gram-positive sepsis. We investigated the influence of the major exotoxin of Staphylococcus aureus, staphylococcal alpha-toxin
D Walmrath et al.
American journal of respiratory and critical care medicine, 154(2 Pt 1), 460-468 (1996-08-01)
Both endotoxin (lipopolysaccharides of gram-negative bacteria; LPS) and bacterial exotoxins may induce pulmonary microcirculatory disturbances when infused into the lung vasculature, and synergism between these types of microbial challenge has recently been noted. We now asked whether a bronchoalveolar LPS
Anna K Leal et al.
American journal of physiology. Heart and circulatory physiology, 301(5), H2140-H2146 (2011-08-23)
Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstitium are increased by exercise
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