D5794

Diacylglycerol Kinase Inhibitor II

solid

• Synonym(e): 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949
• Empirische Formel (Hill-System): C₂₈H₂₅F₂N₃OS
• CAS-Nummer: 120166-69-0
• Molekulargewicht: 489.58
• MDL-Nummer: MFCD00069258
• UNSPSC-Code: 41106300
• PubChem Substanz-ID: 24278378
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥97% (HPLC)
• Form: solid
• Farbe: pale yellow
• mp (Schmelzpunkt): 228-230 °C
• Löslichkeit: 0.1 M HCl: slightly soluble; 0.1 M NaOH: slightly soluble; DMSO: soluble; H₂O: insoluble; ethanol: soluble; ethyl acetate: soluble
• Lagertemp.: −20°C
• SMILES String: Fc1ccc(cc1)\C(=C2\CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5
• InChI: 1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
• InChIKey: ZCNBZFRECRPCKU-UHFFFAOYSA-N

Beschreibung

Anwendung

Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.

Biochem./physiol. Wirkung

Diacylglycerol kinase inhibitor. Inhibits formation of [³⁸P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC₅₀ = 3.3 μM.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves