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D1068

Sigma-Aldrich

DCB

≥98% (HPLC), solid

Synonym(e):

3,3′-Dichlorobenzaldazine, NSC 67224

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About This Item

Empirische Formel (Hill-System):
C14H10Cl2N2
CAS-Nummer:
6971-97-7
Molekulargewicht:
277.15
MDL-Nummer:
MFCD00556081
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724458
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated
under inert gas

Farbe

yellow

Löslichkeit

DMSO: ~6.8 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

InChIKey

XMOVWXSCYLINBJ-BEQMOXJMSA-N

Biochem./physiol. Wirkung

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
O'Brien JA, et al.
Molecular Pharmacology, 64(3), 731-740 (2003)
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PLoS genetics, 13(6), e1006832-e1006832 (2017-06-13)
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