D0676

Dobutamin -hydrochlorid

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

• Synonym(e): (±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₈H₂₃NO₃ · HCl
• CAS-Nummer: 49745-95-1
• Molekulargewicht: 337.84
• EG-Nummer: 256-464-1
• MDL-Nummer: MFCD00153795
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24277772
• NACRES: NA.77

Eigenschaften

• product name: Dobutamin -hydrochlorid, ≥98%
• Qualitätsniveau: 200
• Assay: ≥98%
• Form: powder
• Ersteller: Eli Lilly
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
• InChI: 1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
• InChIKey: BQKADKWNRWCIJL-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRB1(153) , ADRB2(154)

Beschreibung

Anwendung

Dobutamine hydrochloride has been used:

• to treat mouse embryonic fibroblasts for cell death analysis
• to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
• as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem./physiol. Wirkung

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Leistungsmerkmale und Vorteile

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332,H361fd
• P-Sätze: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges