C6506

4-Chlor-DL-Phenylalanin

• Synonym(e): PCP, PCPA
• Lineare Formel: ClC₆H₄CH₂CH(NH₂)CO₂H
• CAS-Nummer: 7424-00-2
• Molekulargewicht: 199.63
• EG-Nummer: 231-051-9
• MDL-Nummer: MFCD00002601
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24278081
• NACRES: NA.32

Eigenschaften

• Form: solid
• Grünere Alternativprodukt-Bewertung: old score: 2; new score: 1; Find out more about DOZN™ Scoring
• Grünere Alternativprodukt-Eigenschaften: Less Hazardous Chemical Syntheses; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• mp (Schmelzpunkt): >240 °C (dec.) (lit.)
• Grünere Alternativprodukt-Kategorie: , Re-engineered
• Lagertemp.: room temp
• SMILES String: NC(Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
• InChIKey: NIGWMJHCCYYCSF-UHFFFAOYSA-N
• Angaben zum Gen: human ... TPH1(7166) , TPH2(121278)

Beschreibung

Allgemeine Beschreibung

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Anwendung

4-Chloro-DL-phenylalanine has been used:

• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Biochem./physiol. Wirkung

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H317
• P-Sätze: P280 - P301 + P310 + P330 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 3 Oral - Skin Sens. 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges