C5429

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride

• Synonym(e): Z-RR-AMC
• Empirische Formel (Hill-System): C₃₀H₃₉N₉O₆
• CAS-Nummer: 136132-67-7
• Molekulargewicht: 621.69
• MDL-Nummer: MFCD00133576
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24892784
• NACRES: NA.32

Eigenschaften

• Form: powder
• Verunreinigungen: ~4% isopropanol
• Lagertemp.: −20°C
• SMILES String: Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12
• InChI: 1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H
• InChIKey: HLSNWWKWVKPXKI-UHFFFAOYSA-N
• Angaben zum Gen: human ... CTSB(1508) ; mouse ... CTSB(13030) ; rat ... CTSB(64529)

Beschreibung

Amino Acid Sequence

Z-Arg-Arg-AMC

Anwendung

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

• as a cathepsin B substrate in zymography analysis of protease in feces extract.
• in cathepsin B activity assay.
• as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

Substrate

Fluorogenic substrate for cathepsin B.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves