C5366

Chlorisondamine diiodide

≥98% (HPLC), white, solid

• Synonym(e): 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
• Empirische Formel (Hill-System): C₁₄H₂₀Cl₄I₂N₂
• CAS-Nummer: 96750-66-2
• Molekulargewicht: 611.94
• MDL-Nummer: MFCD01074794
• UNSPSC-Code: 12352116
• PubChem Substanz-ID: 24724443
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Farbe: white
• Löslichkeit: H₂O: ≥2 mg/mL; DMSO: >20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• InChIKey: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

Beschreibung

Anwendung

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

Biochem./physiol. Wirkung

Chlorisondamine diiodide mediates ganglionic and central blockade.

Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H400
• P-Sätze: P273 - P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves