C5235

Cytochrome P450 human

4F3B isozyme microsomes, with P450 Reductase and cytochrome b₅, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

• EC-Nummer: 1.6.2.4 (BRENDA, IUBMB)
• MDL-Nummer: MFCD03456520
• UNSPSC-Code: 12161501
• NACRES: NA.47

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
• Form: solution
• Mol-Gew.: 45-60 kDa
• Verpackung: vial of 0.5 nmol
• UniProt-Hinterlegungsnummer: Q08477
• Anwendung(en): cell analysis
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... CYP4F3(4051)

Beschreibung

Biochem./physiol. Wirkung

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.

The CYP4F3B isoform catalyzes the 20-hydroxylation of leukotriene B₄.

Einheitendefinition

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.

Physikalische Form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable