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Merck

C2081

Sigma-Aldrich

Anti-α-Catenin antibody produced in rabbit

whole antiserum

Synonym(e):

Anti-α-Catenin, Alpha Catenin Antibody, Alpha Catenin Antibody - Anti-α-Catenin antibody produced in rabbit

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

whole antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Mol-Gew.

antigen ~102 kDa

Enthält

15 mM sodium azide

Speziesreaktivität

several mammalian species

Methode(n)

dot blot: suitable using α-catenin peptide amino acids 890-901 conjugated to BSA
immunohistochemistry (frozen sections): 1:2,000 using bovine kidney sections
indirect immunofluorescence: 1:2,000 using cultured MDBK cells
microarray: suitable
western blot: 1:4,000 using cultured MDBK cells extract

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CTNNA1(1495)
mouse ... Ctnna1(12385)
rat ... Ctnna1(307505)

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Allgemeine Beschreibung

Catenin are distinct peripheral cytosolic proteins, α, β, and γ -catenin (102 kDa, 94 kDa and 86 kDa, respectively) are found in varying abundance in many developing and adult tissues. Within its conserved regions, α-catenin shows 30% identity to vinculin, a protein found mainly in focal cell-cell and cell substrate adhesions.

Spezifität

Does not cross-react with β-catenin or γ-catenin (plakoglobin).

Immunogen

synthetic peptide corresponding to the C-terminal region (amino acids 890-901) of human/mouse α-catenin conjugated to KLH.

Anwendung

Anti-α-Catenin antibody has been used:
  • in dot blot immunoassay
  • in immunoblotting
  • in immunofluorescence
  • in western blotting
  • in immunoprecipitation
  • in immunofluorescence staining
  • in coimmunoprecipitation

Biochem./physiol. Wirkung

Catenins bind, directly or indirectly, to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Cadherins are transmembrane cell surface glycoprotein molecules that mediate calcium-dependent intercellular interactions and are important for tissue morphogenesis. Catenins link E-cadherin to other integral membrane proteins such as Na+ /K+ -ATPase, or to cytoplasmic proteins such as fodrin, ankyrin, sarcoma (Src) and Yes kinases and are modulated by Wnt-1 protooncogene. They are considered good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. α-Catenin appears to be capable of interacting with N-cadherin and P-cadherin. Absence of α-catenin is found in certain tumor cell lines. Frequent reduction of α-catenin levels in human carcinomas of the esophagus, stomach and colon is also reported. Prostate cancer development appears to be correlated with α-catenin gene deletions.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

ROCK and Dia have opposing effects on adherens junctions downstream of Rho
Sahai, E and Marshall C J
Nature Cell Biology, 4(6), 408-408 (2002)
Cadherins and catenins in development
Huber O, et al.
Current Opinion in Cell Biology, 8(5), 685-691 (1996)
Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of beta-catenin signaling
Li J, et al.
Molecular and cellular biology, 31(6), 1134-1144 (2011)
Structure and biochemistry of cadherins and catenins
Shapiro L and Weis W I
Cold Spring Harbor Perspectives in Biology, 1(3), a003053-a003053 (2009)
alpha-catenin: at the junction of intercellular adhesion and actin dynamics
Kobielak A and Fuchs E
Nature Reviews in Molecular and Cell Biology, 5(8), 614-614 (2004)

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