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Wichtige Dokumente
C0870
CHK1, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(e):
CHEK1
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About This Item
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
Rekombinant
expressed in baculovirus infected Sf9 cells
Qualitätsniveau
Produktlinie
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
Form
buffered aqueous glycerol solution
Spezifische Aktivität
169-229 nmol/min·mg
Mol-Gew.
~82 kDa
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... CHEK1(1111)
Biochem./physiol. Wirkung
CHK1 is a 56 kDa serine/threonine protein kinase that was originally identified in fission yeast to play a role in activation of the DNA damage checkpoint in the G2 phase of the cell cycle. CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia.
Physikalische Form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Rechtliche Hinweise
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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N Walworth et al.
Nature, 363(6427), 368-371 (1993-05-27)
The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or
N C Walworth et al.
Science (New York, N.Y.), 271(5247), 353-356 (1996-01-19)
Exposure of eukaryotic cells to agents that generate DNA damage results in transient arrest of progression through the cell cycle. In fission yeast, the DNA damage checkpoint associated with cell cycle arrest before mitosis requires the protein kinase p56chk1. DNA
Kanae Iijima-Ando et al.
Human molecular genetics, 19(10), 1930-1938 (2010-02-18)
Hyperphosphorylation of the microtubule associated protein tau is detected in the brains of individuals with a range of neurodegenerative diseases including Alzheimer's disease (AD). An imbalance in phosphorylation and/or dephosphorylation of tau at disease-related sites has been suggested to initiate
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