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C0868

Sigma-Aldrich

Chromeceptin

≥98% (HPLC), solid

Synonym(e):

2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene, 94G6

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About This Item

Empirische Formel (Hill-System):
C19H16F3N3O
CAS-Nummer:
331859-86-0
Molekulargewicht:
359.35
MDL-Nummer:
MFCD00815850
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24724431
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow to brown

Löslichkeit

H2O: <2 mg/mL
DMSO: >20 mg/mL

Lagertemp.

−20°C

SMILES String

CN(C)c1ccc2C(c3cccc(c3)C(F)(F)F)C(C#N)=C(N)Oc2c1

InChI

1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3

InChIKey

GVINXTXGDDSXFQ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.

Leistungsmerkmale und Vorteile

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Yongmun Choi et al.
Chemistry & biology, 13(3), 241-249 (2006-04-28)
Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecular pathways that modulate IGF2 signaling, by using chromeceptin, a synthetic
Yongmun Choi et al.
The Journal of biological chemistry, 278(9), 7320-7324 (2002-12-24)
An important step in the postgenomic drug discovery is the construction of high quality chemical libraries that generate bioactive molecules at high rates. Here we report a cell-based approach to composing a focused library of biologically active compounds. A collection
Hyang Sook Seol et al.
Scientific reports, 10(1), 21412-21412 (2020-12-10)
Stemness factors control microRNA expression in cancer stem cells. Downregulation of miR-100 and miR-125b is associated with tumor progression and prognosis of various cancers. Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b

Artikel

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