C0230

Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse

~1 mg/mL, clone 28F3, purified immunoglobulin, buffered aqueous glycerol solution

• MDL-Nummer: MFCD01864149
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 28F3, monoclonal
• Form: buffered aqueous glycerol solution
• Mol-Gew.: antigen 28-30 kDa
• Speziesreaktivität: bovine, human
• Konzentration: ~1 mg/mL
• Methode(n): immunoprecipitation (IP): suitable; western blot: 1:5,000 using normal human fibroblasts or MDBK cells
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: Q96L46
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CAPNS1(826) , CAPNS2(84290)

Beschreibung

Allgemeine Beschreibung

Calpain small subunit 1 (Capns1) is a small regulatory subunit associated with the μ-calpain (calpain 1) and m-calpain (calpain 2). The CAPNS1 gene is mapped to human chromosome 19q13.12.

Immunogen

purified calpain from human placenta.

Anwendung

Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse has been used in immunoprecipitation and immunoblotting.

Biochem./physiol. Wirkung

Calpain small subunit 1 (Capns1) participates in the actin cytoskeleton rearrangement and cell migration events. It is crucial for embryonic development. Capns1 interacts with the Ras GTPase activating protein Src homology 3 domain (SH3) (RasGAP-SH3) domain to regulate cell migration and cell survival. It is essential for calpain activity. Capns1 is associated with the oncogenesis of many tumor types including hepatocellular, colorectal, ovarian, and breast cancer.

Physikalische Form

Solution in 0.02 M sodium phosphate, pH 7.5, and 0.15 M sodium chloride containing 50% glycerol and 3 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable