B7272

4-Bromcalcium-Ionophor A23187

powder

• Synonym(e): 4-Brom-A23187, 4-Brom-calcimycin
• Empirische Formel (Hill-System): C₂₉H₃₆BrN₃O₆
• CAS-Nummer: 76455-48-6
• Molekulargewicht: 602.52
• MDL-Nummer: MFCD00077667
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24891982
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Farbe: yellow
• Löslichkeit: ethanol: 20 mg/mL; DMSO: soluble
• Lagertemp.: 2-8°C
• SMILES String: CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
• InChI: 1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
• InChIKey: LDXQFZZGVTWFCF-FHYGWRBKSA-N

Beschreibung

Anwendung

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca²⁺/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.

Nonfluorescent Ca²⁺ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca²⁺ with fluorescent probes.

Biochem./physiol. Wirkung

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca²⁺ levels.

Sonstige Hinweise

Analog of calcium ionophore A23187

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332,H315,H319,H335
• P-Sätze: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves