B3680

Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse

clone 74219.11, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-BMP-6
• MDL-Nummer: MFCD01321772
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 74219.11, monoclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): capture ELISA: suitable; neutralization: suitable; western blot: 1-2 μg/mL
• Isotyp: IgG2b
• UniProt-Hinterlegungsnummer: P22004
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BMP6(654)

Beschreibung

Allgemeine Beschreibung

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP-6 regulates both T cell and B cell-mediated immunity. It acts through Smad and p38 pathway to induce the expression of IL-6. Additionally, it induces the expression of iNOS by macrophages through the activation of NF-κB and STAT pathways. BMP-6 is a stimulator of differentiation of liver, bone, neuronal tissue and embryonic kidney and urinary systems. Studies also indicate that BMP-6 is important in the regulation of liver hormone, hepcidin, expression that is important to maintain systemic iron balance
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.

Immunogen

recombinant human BMP-6.

Anwendung

Anti-Bone Morphogenetic Protein 6 antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For capture ELISA a concentration of 4 μg/ml is recommemnded. The antibody is also suitable for neutralization reactions.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Angaben zur Herstellung

Purified using protein G.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)