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B2517

Sigma-Aldrich

(1′R,2′S)-Biopterin

≥97%

Synonym(e):

2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridin, 6-Biopterin, L-erythro-6-(1,2-Dihydroxypropyl)pterin

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About This Item

Empirische Formel (Hill-System):
C9H11N5O3
CAS-Nummer:
22150-76-1
Molekulargewicht:
237.22
Beilstein:
87860
EG-Nummer:
244-807-8
MDL-Nummer:
MFCD00036787
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24891654
NACRES:
NA.51

Qualitätsniveau

200

Assay

≥97%

Form

powder

Lagertemp.

2-8°C

SMILES String

C[C@H](O)[C@H](O)c1cnc2NC(N)=NC(=O)c2n1

InChI

1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1

InChIKey

LHQIJBMDNUYRAM-DZSWIPIPSA-N

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Anwendung

6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCD8434
BCBZ8817
BCBW0903
BCBR9004V
BCBM4505V

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2,4-Diamino-6-(hydroxymethyl)pteridin 95%

Sigma-Aldrich

861634

2,4-Diamino-6-(hydroxymethyl)pteridin

Dihydrofolsäure ≥90%

Sigma-Aldrich

D7006

Dihydrofolsäure

Medium 199 With Hanks′ salts and L-glutamine, without sodium bicarbonate, powder, suitable for cell culture

Sigma-Aldrich

M0393

Medium 199

Hämin from bovine, ≥90%

Sigma-Aldrich

H9039

Hämin

Isochinolin 97%

Sigma-Aldrich

I28208

Isochinolin

Sanjeewa Gamagedara et al.
Clinica chimica acta; international journal of clinical chemistry, 412(1-2), 120-128 (2010-09-28)
Biomarkers are good potential tools for early cancer diagnosis. Here we have analyzed eight different pteridines in the urine samples of cancer patients and compared them with samples from healthy subjects. Pteridines are important cofactors in the process of cell
Adrien Weingärtner et al.
PloS one, 7(8), e42070-e42070 (2012-08-08)
The protozoan parasite Leishmania is an intracellular pathogen infecting and replicating inside vertebrate host macrophages. A recent model suggests that promastigote and amastigote forms of the parasite mimic mammalian apoptotic cells by exposing phosphatidylserine (PS) at the cell surface to
Suzanne V Saenko et al.
BMC biology, 11, 105-105 (2013-10-09)
Color traits in animals play crucial roles in thermoregulation, photoprotection, camouflage, and visual communication, and are amenable to objective quantification and modeling. However, the extensive variation in non-melanic pigments and structural colors in squamate reptiles has been largely disregarded. Here
Eugenia Bifeld et al.
mSystems, 3(6) (2018-12-07)
The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is
Jarl Underhaug et al.
Current topics in medicinal chemistry, 12(22), 2534-2545 (2013-01-24)
Phenylketonuria (PKU) is a loss-of-function inborn error of metabolism. As many other inherited diseases the main pathologic mechanism in PKU is an enhanced tendency of the mutant phenylalanine hydroxylase (PAH) to misfold and undergo ubiquitin-dependent degradation. Recent alternative approaches with
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