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B1532

Sigma-Aldrich

Resorufin benzyl ether

CYP450 substrate

Synonym(e):

7-Benzyloxy-3H-phenoxazin-3-one, 7-Benzyloxyresorufin, O7-Benzylresorufin

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About This Item

Empirische Formel (Hill-System):
C19H13NO3
CAS-Nummer:
87687-02-3
Molekulargewicht:
303.31
MDL-Nummer:
MFCD00171613
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24891597
NACRES:
NA.32

Qualitätsniveau

200

Assay

≥98% (TLC)

Form

powder

Löslichkeit

chloroform: 9.80-10.20 mg/mL, clear, orange

Lagertemp.

2-8°C

SMILES String

O=C1C=CC2=Nc3ccc(OCc4ccccc4)cc3OC2=C1

InChI

1S/C19H13NO3/c21-14-6-8-16-18(10-14)23-19-11-15(7-9-17(19)20-16)22-12-13-4-2-1-3-5-13/h1-11H,12H2

InChIKey

XNZRYTITWLGTJS-UHFFFAOYSA-N

Substrate

Fluorimetric substrate for cytochrome P450-linked enzymes.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Proadifen -hydrochlorid analytical standard, ≥95%

Supelco

P1061

Proadifen -hydrochlorid

Shosaku Kashiwada et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 141(4), 338-348 (2005-08-23)
Phylogenic analysis of the teleost genomic lineages has demonstrated the precedent for multiple genome duplications. Among many of the genes duplicated, cytochrome P450 genes have undergone independent diversification, which can be traced to a single ancestral gene. In teleosts, cytochrome
R W Nims et al.
The Journal of pharmacology and experimental therapeutics, 270(1), 348-355 (1994-07-01)
To explore further the structural requirements for ligand interaction with the putative phenobarbital receptor, the pharmacodynamics of CYP2B induction by 5,5-diphenylbarbituric acid, phenytoin (5,5-diphenylhydantoin), barbital (5,5-diethylbarbituric acid) and 5,5-diethylhydantoin were investigated in the male F344/NCr rat. Steady-state total (free plus
Lana X Garmire et al.
Pharmaceutical research, 24(12), 2171-2186 (2007-08-19)
Validate and exemplify a discrete, componentized, in silico, transwell device (ISTD) capable of mimicking the in vitro passive transport properties of compounds through cell monolayers. Verify its use for studying drug-drug interactions. We used the synthetic modeling method. Specialized software
H Y Yang et al.
Molecular pharmacology, 46(5), 922-928 (1994-11-01)
Expression of functional cytochrome P450 (CYP) isoforms in human embryonic tissues was explored during organogenesis (days 50-60 of gestation) with substrate probes, inhibitor probes, and immunoprobes and by reverse transcription-polymerase chain reaction (PCR), cloning, and sequencing. Evidence was obtained for
Y Lin et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(4 Pt 1), 368-374 (2001-03-22)
Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by classical Michaelis-Menten kinetic parameters (e.g., Km and Vmax), which are usually determined by a saturation profile of velocity of product formation versus substrate concentration. In turn, these parameters may
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Artikel

Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

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