AV41699

Anti-PKLR antibody produced in rabbit

IgG fraction of antiserum

• Synonym(e): Anti-PK1, Anti-PKL, Anti-Pyruvate kinase, liver and RBC, Anti-RPK
• UNSPSC-Code: 12352203
• NACRES: NA.41
• Konjugat: unconjugated
• application: IHC; WB
• Klon: polyclonal
• Speziesreaktivität: human, rat, pig, rabbit, bovine, dog, mouse
• citations: 5
• Methode(n): immunohistochemistry: suitable; western blot: suitable

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 58 kDa
• Speziesreaktivität: human, rat, pig, rabbit, bovine, dog, mouse
• Konzentration: 0.5 mg - 1 mg/mL
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_000289
• UniProt-Hinterlegungsnummer: P30613-2
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PKLR(5313)

Beschreibung

Allgemeine Beschreibung

Pyruvate kinase (PKLR) is a liver/erythrocyte-specific enzyme that exists as a tetramer. It comprises structural and functional domains namely N. A and C domains. The C domain is erythrocyte-specific and the A domain is active site residues. The PKLR gene is mapped to human chromosome 1q22.

Immunogen

Synthetic peptide directed towards the N terminal region of human PKLR

Anwendung

Anti-PKLR antibody produced in rabbit has been used in western blotting.

Biochem./physiol. Wirkung

Pyruvate kinase (PKLR) is needed for energy generation in erythrocytes. Deficiency of PKLR in mice reduces the risk of blood-stage malarial parasite Plasmodium chabaudi induced infection.

Sequenz

Synthetic peptide located within the following region: STSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVRE

Physikalische Form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable