A2478

APHA Compound 8

≥98% (HPLC), solid

• Synonym(e): 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
• Empirische Formel (Hill-System): C₁₆H₁₆N₂O₃
• CAS-Nummer: 676599-90-9
• Molekulargewicht: 284.31
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329770785
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
• InChI: 1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
• InChIKey: UFQOXIMRSMFQRI-BQYQJAHWSA-N

Beschreibung

Biochem./physiol. Wirkung

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302 - H317 - H318
• P-Sätze: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves