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82934

Sigma-Aldrich

7-Hydroxycitronellal

Odorant used in allergy studies

Synonym(e):

7-Hydroxy-3,7-dimethyl-octanal, Citronellalhydrat

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About This Item

Empirische Formel (Hill-System):
C10H20O2
CAS-Nummer:
107-75-5
Molekulargewicht:
172.26
EG-Nummer:
203-518-7
MDL-Nummer:
MFCD00014681
UNSPSC-Code:
12352200
PubChem Substanz-ID:
57652938
NACRES:
NA.52

Qualität

for molecular biology

Assay

≥95.0% (GC)

Form

powder

Dichte

0.92 g/mL at 20 °C (lit.)

Lagertemp.

room temp

SMILES String

[H]C(CC(C)CCCC(O)(C)C)=O

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

InChIKey

WPFVBOQKRVRMJB-UHFFFAOYSA-N

Allgemeine Beschreibung

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

Anwendung

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Analysenzertifikate (COA)

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Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
Clarissa D Villarama et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1719-1725 (2004-09-08)
The clinical relevance of patch test reactions is often difficult to determine. Use tests have been developed to further evaluate the significance of patch test results. We review studies that have defined correlations between the threshold concentrations at patch testing
S Heydorn et al.
Contact dermatitis, 48(6), 324-330 (2003-10-09)
Recently, we showed that 10 x 2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch
Susan P Felter et al.
Regulatory toxicology and pharmacology : RTP, 37(1), 1-10 (2003-03-29)
The National Academy of Science (NAS) risk assessment paradigm has been widely accepted as a framework for estimating risk from exposure to environmental chemicals (NAS, 1983). Within this framework, quantitative risk assessments (QRAs) serve as the cornerstone of health-based exposure
M Krasteva et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 26(5), 563-570 (1996-05-01)
The need to develop predictive tests which could identify potential allergens has been recognized for many years. There is as yet no accepted in vitro method for the assessment of contact sensitizers. We have tested the ability of a range
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