76548

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamin

≥97.0% (TLC)

• Synonym(e): (9Z)-9-Octadecensäure-(1R)-1-[[[(2-aminoethoxy)-hydroxyphosphinyl]-oxy]-methyl]-1,2-ethandiylester, 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamin, 3-sn-Phosphatidylethanolamin, 1,2-dioleoyl, L-β,γ-Dioleoyl-α-cephalin, DOPE, Dioleoylphosphatidylethanolamin, PE(18:1(9Z)/18:1(9Z))
• Empirische Formel (Hill-System): C₄₁H₇₈NO₈P
• CAS-Nummer: 4004-05-1
• Molekulargewicht: 744.03
• Beilstein: 1718431
• MDL-Nummer: MFCD00057986
• UNSPSC-Code: 51191904
• PubChem Substanz-ID: 329767176
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥97.0% (TLC)
• Form: solid
• Funktionelle Gruppe: amine
• Lipid-Typ: phosphoglycerides
• Lagertemp.: −20°C
• SMILES String: CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
• InChI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-
• InChIKey: MWRBNPKJOOWZPW-CLFAGFIQSA-N

Beschreibung

Anwendung

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents .

Biochem./physiol. Wirkung

DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)