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406OA-05A

Sigma-Aldrich

Human Osteoblasts-Osteoarthritis: HOb-OA, adult

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About This Item

UNSPSC-Code:
41106514
NACRES:
NA.81

Biologische Quelle

human bone (osteoarthritic)

Qualitätsniveau

100

Verpackung

pkg of 500,000 cells

Hersteller/Markenname

Cell Applications, Inc

Wachstumsmodus

Adherent

Karyotyp

2n = 46

Morphologie

osteoblast

Methode(n)

cell culture | mammalian: suitable

Relevante Krankheit(en)

arthritis

Versandbedingung

dry ice

Lagertemp.

−196°C

Verwandte Kategorien

Allgemeine Beschreibung

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Human Osteoblasts-Osteoarthritis, HOb-OA, are isolated from bone of patients with osteoarthritis (OA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.

Characterization: Positive for bone mineralization.

Ursprung der Zelllinie

Bone

Anwendung

model system to study the pathophisiology of osteoarthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism

Komponenten

Basal Medium containing 10% FBS & 10% DMSO

Angaben zur Herstellung

  • 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

Subkultur-Routine

Please refer to the HOb-OA Culture Protocol.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Xiangxiang Sun et al.
International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory cytokines are controlled by inflammasomes, especially NLRP1 (NLR Family Pyrin Domain Containing 1) and NLRP3.

Protokolle

Human Osteoblasts Osteoarthritis (HOb-OA) Culture Protocol

Store the cryovials in a liquid nitrogen storage tank immediately upon arrival.

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