SMB00947

N-Desethyl amodiaquine dihydrochloride

≥95%

• Synonym(e): Monodesethylamodiaquine dihydrochloride
• Empirische Formel (Hill-System): C₁₈H₁₈ClN₃O · 2HCl
• CAS-Nummer: 79049-30-2
• Molekulargewicht: 400.73
• UNSPSC-Code: 41116107
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥95%
• Form: solid
• Mol-Gew.: 400.73 g/mol
• Methode(n): HPLC: suitable
• Farbe: yellow to dark yellow
• Löslichkeit: DMSO: soluble; methanol: soluble; water: soluble
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.

Metabolomics research

Sonstige Hinweise

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable