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RDD039

Sigma-Aldrich

Imidazol

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri™

Synonym(e):

1,3-Diaza-2,4-cyclopentadien, Glyoxalin

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About This Item

Empirische Formel (Hill-System):
C3H4N2
CAS-Nummer:
288-32-4
Molekulargewicht:
68.08
Beilstein:
103853
MDL-Nummer:
MFCD00005183
UNSPSC-Code:
12352200
NACRES:
NA.21

Qualität

Molecular Biology
for molecular biology
free-flowing

Qualitätsniveau

100

Dampfdruck

<1 mmHg ( 20 °C)

Produktlinie

Redi-Dri™

Assay

≥99% (titration)

Form

crystalline powder

pH-Wert

6.2-7.8 (25 °C)

pKa (25 °C)

6.95

bp

256 °C (lit.)

mp (Schmelzpunkt)

88-91 °C (lit.)

Anwendung(en)

diagnostic assay manufacturing

Fremdaktivität

DNase, RNase and protease, none detected

SMILES String

c1c[nH]cn1

InChI

1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)

InChIKey

RAXXELZNTBOGNW-UHFFFAOYSA-N

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Allgemeine Beschreibung

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.

Anwendung

Hervorragend geeignet für Puffer im pH-Bereich von 6,2–7,8
Imidazole has been used
  • in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
  • in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
  • as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

Biochem./physiol. Wirkung

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

Leistungsmerkmale und Vorteile

  • Qualified for molecular biology applications, DNase, Rnase, and protease free
  • Redi-Dri™ packaging controls moisture, eliminating clumps
  • Crystalline powder remains free-flowing and much easier to use
  • Safer to handle and weigh out for routine use in lab
  • Less waste, loss of drying, while maintaining high quality

Sonstige Hinweise

For additional information on our range of Biochemicals, please complete this form.

Rechtliche Hinweise

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

293.0 °F - closed cup

Flammpunkt (°C)

145 °C - closed cup

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLCG7433

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Hochman E, et al.
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Cell, 163(3), 759-771 (2015-10-01)
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multi-protein complexes, whereas class 2 effectors rely on single-component effector proteins such as the well-characterized Cas9. Here
Alan M Sandercock et al.
Molecular cancer, 14, 147-147 (2015-08-01)
Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of
Pam M Van Ry et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(8), 1285-1297 (2015-06-09)
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex. Galectin-1 is a small 14 kDa protein normally found in skeletal
Ali Tebbi et al.
The Journal of biological chemistry, 290(22), 14077-14090 (2015-04-17)
Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S
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Redi-Dri™ – The World of Free-flowing Hygroscopic Products

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