F6377

Fluoreszein Natriumsalz

Powder

• Synonym(e): Acid Yellow 73, D&C; Gelb Nr. 8, NaFl, NaFluo, Natriumfluorescein, Uranin
• Empirische Formel (Hill-System): C₂₀H₁₀Na₂O₅
• CAS-Nummer: 518-47-8
• Molekulargewicht: 376.27
• Farbindexnummer: 45350
• Beilstein: 3833041
• EG-Nummer: 208-253-0
• MDL-Nummer: MFCD00167039
• UNSPSC-Code: 12171500
• PubChem Substanz-ID: 24894907
• NACRES: NA.47

Eigenschaften

• product name: Fluoreszein Natriumsalz, used as fluorescent tracer
• Qualitätsniveau: 200
• Form: powder
• Farbe: orange to brown
• pH-Wert: 8.3 (20 °C, 10 g/L)
• mp (Schmelzpunkt): >300 °C
• Löslichkeit: H₂O: 1 mg/mL
• Dichte: 0.78 g/cm³ at 29.6 °C (85.3 °F at 699.7 hPa)
• Fluoreszenz: λ_ex 460 nm; λ_em 515 nm(lit.)
• Anwendung(en): diagnostic assay manufacturing; hematology; histology
• Lagertemp.: room temp
• SMILES String: [Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1
• InChI: 1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2
• InChIKey: RGPLGPBQJOQFJS-UHFFFAOYSA-L

Beschreibung

Allgemeine Beschreibung

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Anwendung

Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.

Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): 423.7 °F - Pensky-Martens closed cup
• Flammpunkt (°C): 217.6 °C - Pensky-Martens closed cup
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)