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Merck

D7439

Supelco

Dihydroartemisinin

analytical standard, mixture of α and β isomers

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About This Item

Empirische Formel (Hill-System):
C15H24O5
Molekulargewicht:
284.35
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥97% (TLC)

Form

powder

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

C[C@H]1C(O)O[C@@]2([H])[C@@]3(OO4)[C@](CC[C@]4(C)O2)([H])[C@H](C)CC[C@]31[H]

InChI

1S/C15H24O5/c1-8-4-5-10-9(2)12(16)18-13-15(10)11(8)6-14(3,7-17-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13+,14+,15+/m1/s1

InChIKey

DJGUTYJDEZGRGH-NJEKVMANSA-N

Allgemeine Beschreibung

Dihydroartemisinin is the major metabolite of the antimalarial agent, artemether. It is highly efficient against both drug-sensitive and drug-resistant strains of Plasmodium falciparum.
Antimalaria-, Antipsoriasis-Wirkstoff; entzündungshemmend

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Warnhinweis

Vor Licht schützen

Angaben zur Herstellung

artemisia Pflanzenextrakt

Piktogramme

FlameEnvironment

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Aquatic Chronic 2 - Org. Perox. C

Lagerklassenschlüssel

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

Anne Marijon et al.
Malaria journal, 13, 501-501 (2014-12-18)
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field
Zenglei Wang et al.
PloS one, 9(4), e93825-e93825 (2014-04-17)
Malaria elimination/eradication campaigns emphasize interruption of parasite transmission as a priority strategy. Screening for new drugs and vaccines against gametocytes is therefore urgently needed. However, current methods for sexual stage drug assays, usually performed by counting or via fluorescent markers
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas GC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 131-136 (1992)
Emily Caton et al.
Antimicrobial agents and chemotherapy, 63(11) (2019-08-28)
Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed
Anais Laleve et al.
Biochimica et biophysica acta. Molecular cell research, 1867(5), 118661-118661 (2020-01-29)
Artemisinin and its derivatives kill malaria parasites and inhibit the proliferation of cancer cells. In both processes, heme was shown to play a key role in artemisinin bioactivation. We found that artemisinin and clinical artemisinin derivatives are able to compensate

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