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Merck

B3916

Supelco

Boldin

analytical standard

Synonym(e):

2,9-Dihydroxy-1,10-dimethoxy-aporphin

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About This Item

Empirische Formel (Hill-System):
C19H21NO4
CAS-Nummer:
Molekulargewicht:
327.37
Beilstein:
94036
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Biologische Quelle

plant (Peumus boldus molina)

Qualitätsniveau

Qualität

analytical standard

Assay

≥98% (TLC)

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Verunreinigungen

≤1% isopropanol

mp (Schmelzpunkt)

157-164  °C

Löslichkeit

ethanol: 50 mg/mL

Anwendung(en)

food and beverages
forensics and toxicology
veterinary

Format

neat

Lagertemp.

room temp

SMILES String

COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O

InChI

1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

InChIKey

LZJRNLRASBVRRX-ZDUSSCGKSA-N

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Allgemeine Beschreibung

Boldine is an aporphine alkaloid isolated from Boldo tree and other plant species. It is a free radical scavenger with anti-inflammatory activity while exhibiting other pharmacological effects such as antidiabetic, antiplatelet aggregation, antipyretic, antinociceptive, antiatherogenic, hepatoprotective and endothelium-protective activity.

Anwendung

Boldine may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical preparations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Franz A Thomet et al.
Molecules (Basel, Switzerland), 16(3), 2253-2258 (2011-03-09)
2,9-Dimethoxymethylboldine (2), 2,9-dimethoxymethyl-3-bromoboldine (3) and 2,9-dimethoxymethyl-3-diphenylphosphinylboldine (4) have been synthesized in an effort to find compounds with potential pharmacological applications. The cytotoxic activities of the natural precursor 1 and these three derivatives have been measured as IC₅₀ inhibitory growth. The
Yeh Siang Lau et al.
Biochemical pharmacology, 85(3), 367-375 (2012-11-28)
Increased oxidative stress is involved in the pathogenesis and progression of diabetes. Antioxidants are therapeutically beneficial for oxidative stress-associated diseases. Boldine ([s]-2,9-dihydroxy-1,10-dimethoxyaporphine) is a major alkaloid present in the leaves and bark of the boldo tree (Peumus boldus Molina), with
Qi-Zhi Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 40(10), 931-934 (2006-01-18)
To study the alkaloid constituents of the root of Lindera angustifolia Cheng. The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis. Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV)
Lip Yong Chung et al.
Phytotherapy research : PTR, 23(3), 330-334 (2008-10-11)
A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two compounds identified as
Bangning Yu et al.
Journal of medicinal food, 12(5), 1074-1083 (2009-10-28)
Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease. Natural compounds that can prevent oxidative stress mediated inhibition of adiponectin may

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