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Merck

46429

Supelco

Methimazol

VETRANAL®, analytical standard

Synonym(e):

1-Methyl-2-imidazolthiol, 2-Mercapto-1-methylimidazol

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About This Item

Empirische Formel (Hill-System):
C4H6N2S
CAS-Nummer:
Molekulargewicht:
114.17
Beilstein:
108646
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Produktlinie

VETRANAL®

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

144-147 °C (lit.)

Anwendung(en)

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

Format

neat

SMILES String

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChIKey

PMRYVIKBURPHAH-UHFFFAOYSA-N

Angaben zum Gen

human ... TPO(7173)

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Allgemeine Beschreibung

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Anwendung

Methimazole may be used as a reference standard for the determination of the analyte in fish homogenates using mixed mode solid-phase extraction technique with reversed-phase high-performance liquid chromatography method with ultraviolet detection (MMSPE-RP-HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

Health hazardExclamation mark

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Yi Wang et al.
Toxicology and applied pharmacology, 271(2), 257-265 (2013-05-28)
Neurotoxicity of iodine deficiency-induced hypothyroidism during developmental period results in serious impairments of brain function, such as learning and memory. These impairments are largely irreversible, and the underlying mechanisms remain unclear. In addition to hypothyroidism, iodine deficiency may cause hypothyroxinemia
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient
Mal-Soon Shin et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(3), 214-223 (2013-01-19)
Thyroid hormones play a crucial role in new neuron production and maturation during brain development. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise
F S Boretti et al.
Journal of veterinary internal medicine, 27(2), 377-381 (2013-02-13)
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole application. Such information would be valuable for therapeutic monitoring. To assess variation in serum

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