22642

Chinin -hemisulfat (Salz) Monohydrat

tested according to Ph. Eur.

• Synonym(e): Chinini sulfas, Chinin-sulfat (2:1) (Salz) Dihydrat
• Empirische Formel (Hill-System): C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• CAS-Nummer: 207671-44-1
• Molekulargewicht: 391.47
• Beilstein: 6113937
• MDL-Nummer: MFCD00150790
• UNSPSC-Code: 12352210
• PubChem Substanz-ID: 329752331
• NACRES: NA.25

Eigenschaften

• Agentur: USP/NF; tested according to Ph. Eur.
• Qualitätsniveau: 100
• mp (Schmelzpunkt): ~225 °C (dec.) (lit.)
• Wirkungsspektrum von Antibiotika: parasites
• Wirkungsweise: enzyme | inhibits
• SMILES String: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
• InChIKey: ZHNFLHYOFXQIOW-LPYZJUEESA-N

Beschreibung

Anwendung

Quinine hemisulfate salt monohydrate has been used as a tastant for testing the saccharin and quinine consumption in wild-type or knock-in mice. It has been used for studying the toxicity of heme (FP)-complexes.

Biochem./physiol. Wirkung

blockiert Kaliumkanäle. Anti-Malaria, anticholinerges, antihypertensives und hypoglykemisches Agens; ursprünglich aus südafrikanischen Bäumen der Gattung Cinchona isoliert.

Quinine hemisulfate is an alkaloid originally isolated from the Cinchona family of South American trees. It inhibits mitochondrial ATP-regulated potassium channel and posssess antimalarial, anticholinergic, antihypertensive and hypoglycemic properties.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves