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Key Documents

MABX1911

Sigma-Aldrich

Anti-human IgM (10mg) KC

from mouse

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Antikörperform

purified antibody

Antikörper-Produkttyp

secondary antibodies

Klon

monoclonal

Speziesreaktivität

human

Methode(n)

ELISA: suitable
immunodiffusion: suitable

Isotyp

IgG1

Allgemeine Beschreibung

Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.

Spezifität

Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.

Immunogen

corresponding to Human Human Serum IgM.

Anwendung

Research Category
Sekundär- & Kontrollantikörper
Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None

Biochem./physiol. Wirkung

Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.

Qualität

Tested

Physikalische Form

Ion-exchange chromatography
Format: Purified
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).

Lagerung und Haltbarkeit

2-8°C. For long-term storage, freeze at -20°C.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Michael R Ehrenstein et al.
Nature reviews. Immunology, 10(11), 778-786 (2010-10-16)
The existence of IgM has been known for more than a century, but its importance in immunity and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have provided unexpected insights into its role in several diverse processes

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