MABF240

Anti-hGITR Antibody, clone 108-17

clone 108-17, from mouse

• Synonym(e): Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 108-17, monoclonal
• Speziesreaktivität: mouse, human, rat
• Methode(n): western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_004186
• UniProt-Hinterlegungsnummer: Q9Y5U5
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TNFRSF18(8784)

Beschreibung

Allgemeine Beschreibung

Glucocorticoid-induced TNFR-related protein (hGITR) is also called Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), Activation-inducible TNFR family receptor (AITR) and CD357. hGITR is a receptor for TNFSF18 and is activated by NF-kappa-B through the TRAF2/NIK pathway. hGITR is thought to be involved in activated T-lymphocyte and endothelial cell interactions, as well as regulation of T-cell receptor-mediated cell death. hGITR is expressed in lymph node, peripheral blood leukocytes and at low levels in the spleen.

Immunogen

Recombinant protein corresponding to human hGITR.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

Anti-hGITR Antibody, clone 108-17 is a highly specific mouse monoclonal antibody & that targets GITR & has been tested in western blotting.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected hGITR in 10 µg of mouse lymph node, rat spleen, and rat thymus tissue lysate.

Qualität

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected hGITR in 10 µg of human spleen tissue lysate.

Zielbeschreibung

~ 26 kDa observed. Multiple bands can be observed due to GITR being a monomer & homeodimer in some lysates. Uncharacterized band(s) may appear in some lysates.

Physikalische Form

Protein A purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable