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MAB4331

Sigma-Aldrich

Anti-MELK Antibody, clone 6C1.3

clone 6C1.3, Chemicon®, from mouse

Synonym(e):

Maternal Embryonic Leucine Zipper Kinase

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

6C1.3, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Chemicon®

Methode(n)

western blot: suitable

Aufnahme

sample type neural stem cell(s)

Isotyp

IgG2κ

NCBI-Hinterlegungsnummer

NM_014791.2

UniProt-Hinterlegungsnummer

Q14680

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MELK(9833)

Allgemeine Beschreibung

Melk, (Maternal Embryonic Leucine Zipper Kinase) is a serine-threonine kinase of the snfI/AMPK family that is expressed in developing neuroepithelium, self-renewing neural stem cells and granule cell precursors. It is also considered an important brain tumor marker, being highly expressed in gliobastoma, astrocytomas, and medulablastomas.

Immunogen

MELK Recombinant protein.

Anwendung

Research Category
Stammzellforschung
Research Sub Category
Neurale Stammzellen
This Anti-MELK Antibody, clone 6C1.3 is validated for use in WB for the detection of MELK.
Western blot: Recommended dilution: 1:500 (2 μg/mL)
Expected Molecular Weight: 74.5 kDa
Note: Bands may be present at a higher molecular weight due to glycosolation.

Zielbeschreibung

74.5 kDA; glycosylations may result in higher MW bands in western blot.

Physikalische Form

Format: Purified
Purified immunoglobulin in PBS, pH 7.0. Contains 0.1% sodium azide.

Lagerung und Haltbarkeit

1 year at 2-8 °C from date of shipment

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Lieve Verlinden et al.
The Journal of biological chemistry, 280(45), 37319-37330 (2005-09-08)
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) has potent antiproliferative effects characterized by a hampered G(1)/S transition. cDNA microarrays were used to monitor expression of 21,492 genes in MC3T3-E1 mouse osteoblasts at 1, 6, 12, 24, and 36 h after treatment with 1,25(OH)(2)D(3). Statistical
Mathew C Easterday et al.
Developmental biology, 264(2), 309-322 (2003-12-04)
The identification of the genes regulating neural progenitor cell (NPC) functions is of great importance to developmental neuroscience and neural repair. Previously, we combined genetic subtraction and microarray analysis to identify genes enriched in neural progenitor cultures. Here, we apply
Ichiro Nakano et al.
The Journal of cell biology, 170(3), 413-427 (2005-08-03)
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-renewing

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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