Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

MAB2083

Sigma-Aldrich

Anti-γ-Catenin Antibody, clone 11E4

clone 11E4, Chemicon®, from mouse

Synonym(e):

Plakoglobin

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

11E4, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Chemicon®

Methode(n)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_002230.1
NM_021991.1

UniProt-Hinterlegungsnummer

P14923

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... JUP(3728)

Spezifität

Produced by immunization with recombinant human G-catenin.

Anwendung

Research Category
Zellstruktur
Research Sub Category
Cytoskelett
Detect γ-Catenin using this Anti-γ-Catenin Antibody, clone 11E4 validated for use in IP, WB, IC, IH.
Immunohistochemistry: Histochoice fixative is effective.

Immunocytochemistry: Effective for A431 and HT1080 cell lines.

Immunoblotting

Immunoprecipitation

Optimal working dilutions must be determined by end user.

Physikalische Form

Format: Purified
Liquid at 1 mg/mL in 0.02 M phosphate buffer, pH 7.6, 0.25M NaCl, containing 0.1% sodium azide.

Lagerung und Haltbarkeit

Maintain refrigerated at 2-8°C in undiluted aliquots for up to12 months.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.
Nieset, J E, et al.
Journal of Cell Science, 110 ( Pt 8), 1013-1022 (1997)
D Salomon et al.
The Journal of cell biology, 139(5), 1325-1335 (1998-01-07)
beta-Catenin and plakoglobin (gamma-catenin) are closely related molecules of the armadillo family of proteins. They are localized at the submembrane plaques of cell-cell adherens junctions where they form independent complexes with classical cadherins and alpha-catenin to establish the link with
P A Sacco et al.
The Journal of biological chemistry, 270(34), 20201-20206 (1995-08-25)
Cadherins are calcium-dependent, cell surface glycoproteins involved in cell-cell adhesion. To function in cell-cell adhesion, the transmembrane cadherin molecule must be associated with the cytoskeleton via cytoplasmic proteins known as catenins. Three catenins, alpha-catenin, beta-catenin, and gamma-catenin (also known as
Cross-talk between adherens junctions and desmosomes depends on plakoglobin.
Lewis, J E, et al.
The Journal of cell biology, 136, 919-934 (1997)
Xuming Mao et al.
The Journal of biological chemistry, 286(2), 1283-1291 (2010-11-17)
Pemphigus vulgaris (PV) is a potentially fatal blistering disease characterized by autoantibodies against the desmosomal adhesion protein desmoglein (Dsg) 3. Whether autoantibody steric hindrance or signaling through pathways such as p38 MAPK is primary in disease pathogenesis is controversial. PV
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.