HMMP2MAG-55K

MILLIPLEX^® Human MMP Magnetic Bead Panel 2 - Immunology Multiplex Assay

Matrix Metalloproteinase Bead-Based Multiplex Assays using the Luminex technology enable the simultaneous analysis of multiple MMPs biomarkers in human serum, plasma and cell culture samples.

• Synonym(e): Human matrix metalloproteinase multiplex kit, Luminex^® Human MMP immunoassay, Millipore human MMP panel
• UNSPSC-Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Eigenschaften

• Qualitätsniveau: 200
• Speziesreaktivität: human
• Hersteller/Markenname: Milliplex^®
• assay range: accuracy: 72-98%; standard curve range: 14-10,000 pg/mL; (MMP-9); standard curve range: 27-20,000 pg/mL; (MMP-1); standard curve range: 27-20,000 pg/mL; (MMP-10); standard curve range: 548-400,000 pg/mL; (MMP-7); standard curve range: 68-50,000 pg/mL; (MMP-2)
• Methode(n): multiplexing: suitable
• Nachweisverfahren: fluorometric (Luminex xMAP)
• Versandbedingung: wet ice

Beschreibung

Allgemeine Beschreibung

MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in arthritis, cardiovascular disease and tumor growth and metastasis.
MMP/TIMP research plays a significant role in achieving a deeper understanding of disease states such as chronic inflammation, cardiovascular disease, and cancer.

The MILLIPLEX^® Human MMP Bead Panel 2 (MMP-1, -2, -7, -9, -10) will enable you to explore the modulation of and the function of MMP expression in multiple therapeutic areas.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

Spezifität

Cross Reactivty
No significant cross-reactivity was observed among analytes in this panel.

Anwendung

• Analytes: MMP-1, MMP-2, MMP-7, MMP-9, MMP-10
• Recommended Sample type: human serum, plasma, tissue/cell lystate and culture supernatant samples
• Recommended Sample dilution: 1:20
• Assay Run Time: One day
• Research Category: Inflammation & Immunology

Leistungsmerkmale und Vorteile

Design your multiplex kit by choosing available analytes within this panel.

Lagerung und Haltbarkeit

Recommended storage for kit components is 2 - 8°C.

Sonstige Hinweise

Sensitivity: See protocol for sensitivities of individual analytes.

Rechtliche Hinweise

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS08,GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302 + H312 + H332,H317,H318,H373,H411
• P-Sätze: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Zielorgane: Respiratory Tract
• Lagerklassenschlüssel: 10 - Combustible liquids