FCMAB178P

Milli-Mark^® Anti-CD11B-PE Antibody, clone 2LPM19c

clone 2LPM19c, Milli-Mark^®, from mouse

• Synonym(e): Integrin alpha-M, Cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11 antigen-like family member B
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.44

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: PE
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 2LPM19c, monoclonal
• Speziesreaktivität: human
• Hersteller/Markenname: Milli-Mark^®
• Methode(n): flow cytometry: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_000623.2
• UniProt-Hinterlegungsnummer: P11215
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ITGAM(3684)

Beschreibung

Allgemeine Beschreibung

CD11b is the 165 kDa α-chain of the Mac-1 complex. The molecule, also called CR3, functions as a cell surface receptor for the C3bi complement fragment. There is evidence that CD11b can bind fibrinogen in addition to C3bi (Wright,1988). Two binding sites have now been reported, one recognizing lipopolysaccharide, and the other protein ligands containing the arg-gly-asp sequence (Wright, 1989). Binding of the coagulation factor X has also been suggested as an additional receptor role of CD11b (Altieri,1988). This protein belings to a family of related heterodimeric proteins designated CD11 in the classification system for human leucocyte differentiation antigens, which shares a common β-chain with a MW of 95 kDa (CD18). Besides the C3bi receptor, this protein family contains two other members, leucocyte function associated-1 (LFA-1, C11a) antigen and p150,95 protein (CD11c) (Sanchez-Madrid,1983).

Spezifität

Antibody recognizes Human CD11b antigen.

Immunogen

Purified iC3b receptor.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

Milli-Mark Anti-CD11B-PE Antibody, clone 2LPM19c detects level of CD11B & has been published & validated for use in FC.

Qualität

Evaluated by flow cytometry using human PBMCs

Zielbeschreibung

165 kDa (Wright, 1988)

Physikalische Form

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Lagerung und Haltbarkeit

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.

Hinweis zur Analyse

Control
PBMCs

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable