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ABN88

Sigma-Aldrich

Anti-phospho-NR1 (Ser896) Antibody

from rabbit, purified by affinity chromatography

Synonym(e):

glutamate receptor, ionotropic, N-methyl D-aspartate 1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

rat

Speziesreaktivität (Voraussage durch Homologie)

mouse (based on 100% sequence homology), human (based on 100% sequence homology)

Methode(n)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI-Hinterlegungsnummer

NP_058706

UniProt-Hinterlegungsnummer

P35439

Versandbedingung

wet ice

Posttranslationale Modifikation Target

phosphorylation (pSer896)

Angaben zum Gen

human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)

Allgemeine Beschreibung

NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.

Spezifität

This antibody recognizes NR1 when phosphorylated at Ser896.

Immunogen

Epitope: Phosphorylated Ser896
KLH-conjugated linear peptide corresponding to rat NR1 phosphorylated at Ser896.

Anwendung

Detect phospho-NR1 (Ser896) using this Anti-phospho-NR1 (Ser896) Antibody validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:25 dilution from a previous lot detected NR1 in normal rat hippocampus tissue.

Qualität

Evaluated by Western Blot in lambda phosphatase untreated and treated rat microsomal brain tissue lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of lambda phosphatase untreated and treated rat microsomal brain tissue lysates.

Zielbeschreibung

~130kDa observed

Verlinkung

Replaces: 06-640

Hinweis zur Analyse

Control
Lambda phosphatase untreated and treated rat microsomal brain tissue lysates

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Lagerklassenschlüssel

10-13 - German Storage Class 10 to 13

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Jing-Dun Xie et al.
The Journal of biological chemistry, 291(37), 19364-19373 (2016-07-28)
Painful peripheral neuropathy is a severe adverse effect of chemotherapeutic drugs such as paclitaxel (Taxol). The glutamate N-methyl-d-aspartate receptors (NMDARs) are critically involved in the synaptic plasticity associated with neuropathic pain. However, paclitaxel treatment does not alter the postsynaptic NMDAR
Milena De Felice et al.
Molecular pain, 12 (2016-04-21)
Bone metastases occur frequently in advanced breast, lung, and prostate cancer, with approximately 70% of patients affected. Pain is a major symptom of bone metastases, and current treatments may be inadequate or have unacceptable side effects. The mechanisms that drive
Sheu-Ran Choi et al.
Experimental neurobiology, 28(4), 516-528 (2019-09-09)
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory mechanisms responsible for the expression of the DHEA-synthesizing enzyme, cytochrome
Sheu-Ran Choi et al.
Biological & pharmaceutical bulletin, 39(12), 1922-1931 (2016-09-08)
We recently demonstrated that activation of spinal sigma-1 receptors (Sig-1Rs) induces pain hypersensitivity via the activation of neuronal nitric oxide synthase (nNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2). However, the potential direct interaction between nNOS-derived nitric oxide
Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G??A ALS mice: overlapping effects or limited therapeutic opportunity?
Mancuso, R; Del Valle, J; Morell, M; Pallas, M; Osta, R; Navarro, X
Orphanet Journal of Rare Diseases null
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