ABE241

Anti-MBNL1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): muscleblind-like (Drosophila), Triplet-expansion RNA-binding protein, muscleblind (Drosophila)-like, muscleblind-like protein 1, KIAA0428
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: mouse, human, rat
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_066368
• UniProt-Hinterlegungsnummer: Q9NR56
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MBNL1(4154)

Beschreibung

Allgemeine Beschreibung

Muscleblind 1 (MBNL1) is a member of the muscleblind family. MBNL1in involved in pre-mRNA alternative splicing and acts as either splicing activator or repressor on specific pre-mRNA targets. This protein contains four C3H1-type zinc fingers and binds to expanded CUG repeat RNA. High expression of MBNL1 has been observed in cardiac and skeletal muscle as well as in differentiating myoblasts. MBNL1 is known to be involved in the pathogenesis of dystrophia myotonica type 1 (DM1). For those afflicted with this muscular disorder, MBNL1 is sequestered by DMPK RNAs that contain CUG triplet repeat expansions.

Immunogen

Histidine-tagged recombinant protein corresponding to human MBNL1.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
RNA-Stoffwechsel & Bindungsproteine

Use Anti-MBNL1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect MBNL1 also known as muscleblind-like (Drosophila), Triplet-expansion RNA-binding protein.

Qualität

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected MBNL1 on 10 µg of A431 cell lysate.

Zielbeschreibung

~ 33-42 kDa observed. There are three known splice variants ranging from ~33 kDa to ~42 kDa An uncharacterized band at ~ 80 kDa has been observed in some lysates.

Physikalische Form

Affinity purified

Purified rabbit polyclonal in tris-citrate containing 0.1% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
A431 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable