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AB3572P

Sigma-Aldrich

Anti-Organic Anion Transporting Polypeptide 2 Antibody, CT, intracellular

Chemicon®, from rabbit

Synonym(e):

oatp2, OATP-B1, Brain digoxin carrier protein

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

rat

Hersteller/Markenname

Chemicon®

Methode(n)

ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NM_006446.3

UniProt-Hinterlegungsnummer

Q9Y6L6

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

rat ... Slco1A4(170698)

Allgemeine Beschreibung

Organic Anion Transporting Polypeptide 2 is an integral membrane protein that mediates the sodium-independent transport of organic ions, cardiac glycosides and thyroid hormones. Oatp2 is highly expressed in brain, liver, and kidney but not expressed in heart, spleen, lung, skeletal muscle, or testis.

Spezifität

Recognizes rat Organic Ion Transporter 2 Polypeptide 2.

Immunogen

A 12 amino acid peptide sequence near the cytoplasmic, C-terminus of rat OATP2. The immunogen shows no significant sequence similarity to other OATPs or other proteins.

Anwendung

Detect Organic Anion Transporting Polypeptide 2 using this Anti-Organic Anion Transporting Polypeptide 2 Antibody, C-terminus, intracellular validated for use in ELISA & WB.
Western blot: 1-10 μg/mL using ECL. Rat OATP2 is approximately 75 kD in brain and liver (Noe et al. 1997).

ELISA: 0.5-1.0 μg/mL using 1 μg/mL control peptide per well.

Optimal working dilutions must be determined by the end user.

Physikalische Form

Affinity purified immunoglobulin. Liquid in PBS, containing 0.1% BSA.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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T Abe et al.
The Journal of biological chemistry, 273(35), 22395-22401 (1998-08-26)
Two complementary DNAs for the organic anion transporter subtypes oatp2 and oatp3, which transport thyroid hormones as well as taurocholate, were isolated from a rat retina cDNA library. The sequence of oatp2 is identical to that recently reported (Noé, B.
M Kakyo et al.
FEBS letters, 445(2-3), 343-346 (1999-03-27)
The rabbit polyclonal antibody against rat organic anion transporting polypeptide 2 (oatp2) was raised and immunoaffinity-purified. Western blot analysis for oatp2 detected two bands ( 74 and 76 kDa) in rat brain and a single band (76 kDa) in the
Camilla A Thorling et al.
Journal of biomedical optics, 18(10), 101306-101306 (2013-07-03)
The liver is important in the biotransformation of various drugs, where hepatic transporters facilitate uptake and excretion. Ischemia-reperfusion (I/R) injury is a common occurrence in liver surgery, and the developing oxidative stress can lead to graft failure. We used intravital
Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.
Johnson, BM; Zhang, P; Schuetz, JD; Brouwer, KL
Drug Metabolism and Disposition null

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