AB1735

Anti-Bid Antibody

serum, Chemicon^®

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: serum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: mouse, human, rat, rabbit
• Hersteller/Markenname: Chemicon^®
• Methode(n): immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NM_001196.2; NM_197966.1; NM_197967.1
• UniProt-Hinterlegungsnummer: P55957
• Versandbedingung: dry ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BID(637)

Beschreibung

Allgemeine Beschreibung

Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is known to interact with Bcl-2 and Bax. It has been reported that Bid induces cytochrome c release from mitochondria following cleavage by caspase-8 in response to apoptotic stimuli transmitted through cell surface death receptors. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

Spezifität

AB1735 recognizes Bid from human, mouse, rat and rabbit.

Immunogen

Recombinant full length GST-tagged mouse Bid protein

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
BCL2 & Hemmung

Detect Bid using this Anti-Bid Antibody validated for use in WB, IP, IH.

Western blot: Recommended antibody dilution 1:3,000 to 1:6,000. Recognizes a band migrating at approximately 22 kDa corresponding to Bid.

Immunoprecipitation: Recommended antibody dilution 1:200

Immunohistochemistry: Recommended antibody dilution 1:1500

Optimal working dilutions must be determined by end user.

Verlinkung

Replaces: 04-438

Physikalische Form

Whole serum without preservatives

Lagerung und Haltbarkeit

Store at -20°C for up to 12 months.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable