681672

Wnt/β-catenin Inhibitor, Cardamonin

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Wnt/β-catenin Inhibitor, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, Wnt Pathway Inhibitor VII, Cardamonin
• Empirische Formel (Hill-System): C₁₆H₁₄O₄
• CAS-Nummer: 19309-14-9
• Molekulargewicht: 270.28
• MDL-Nummer: MFCD00238554
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: orange-yellow to amber
• Löslichkeit: DMSO: 100 mg/mL; ethanol: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
• InChIKey: NYSZJNUIVUBQMM-BQYQJAHWSA-N

Beschreibung

Allgemeine Beschreibung

Cardamonin, a known 2′,4′-dihydroxy-6′-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.

Cardamonin, a known 2′,4′-dihydroxy-6′-methoxychalcone, was recently identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCa-dependent pathway, rather than a GSK-3&beta:-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable