574713

Syk Inhibitor III

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
• Empirische Formel (Hill-System): C₉H₇NO₄
• CAS-Nummer: 1485-00-3
• Molekulargewicht: 193.16
• MDL-Nummer: MFCD00014575
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (GC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow to brown
• Löslichkeit: DMSO: 25 mg/mL (Use only fresh DMSO.)
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
• InChIKey: KFLWBZPSJQPRDD-ARJAWSKDSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Syk

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.5 µM against Syk kinase activity

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Irritant (B)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3