5.30961

TAZ Activator, IBS008738

• Synonym(e): TAZ Activator, IBS008738, (4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator
• Empirische Formel (Hill-System): C₂₂H₂₂N₄O₂
• CAS-Nummer: 385425-03-6
• Molekulargewicht: 374.44
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 6160351
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 50 mg/mL
• Lagertemp.: −20°C
• SMILES String: CC1=CC=C(C=C1)N2C=NC(=C2C(=O)C3=CC=CC=C3)N=CN4CCOCC4

Beschreibung

Allgemeine Beschreibung

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem./physiol. Wirkung

Cell permeable: yes

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Sonstige Hinweise

Yang, Z., et al. 2014. Mol. Cell. Biol.34, 1607.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable