5.08158

TGF-β

InSolution, ≥99%, 50 mM in DMSO, RI Kinase Inhibitor II, RepSox

• Synonym(e): InSolution TGF-β RI Kinase Inhibitor II, RepSox, RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
• Empirische Formel (Hill-System): C₁₇H₁₃N₅
• CAS-Nummer: 446859-33-2
• Molekulargewicht: 287.32
• MDL-Nummer: MFCD09037561
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99% (HPLC)
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Lagertemp.: −70°C
• InChI: 1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
• InChIKey: LBPKYPYHDKKRFS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC₅₀ = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC₅₀ >16 µM).

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
ALK5

Reversible: yes

Target IC₅₀: 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&beta

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

A 50 mM (5 mg/348 µl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox (Cat. No. 616452) in DMSO.

Rekonstituierung

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilution.

Sonstige Hinweise

Ichida, J. K., et al. 2009. Cell Stem Cell5, 491.
Gellibert, F., et al. 2004. J. Med. Chem.47, 4494.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 188.6 °F - (refers to pure substance)
• Flammpunkt (°C): 87 °C - (refers to pure substance)