5.06272

SB 206553 Hydrochloride

• Synonym(e): SB 206553 Hydrochloride, 5-HT _2C Serotonin Receptor Antagonist, SB 206553, 5-HT _2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553
• Empirische Formel (Hill-System): C₁₇H₁₆N₄O · xHCl
• CAS-Nummer: 158942-04-2
• Molekulargewicht: 292.34 (free base basis)
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 3.2 nM K_i
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: soluble
• Lagertemp.: 2-8°C
• InChI: 1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
• InChIKey: QJQORSLQNXDVGE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A selective 5-HT_2C serotonin receptor inhibitor with lesser affinity for 5-HT_2BR. Often used in conjunction with ketanserin to distinguish 5-HT_2AR and 5-HT_2CR activity. SB206553 has highest affinity for 5-HT_2CR (K_i = 3.2nM) and less for 5-HT_2BR (K_i = 5.5 nM) and 5-HT_2AR (K_i = 2,300 nM).

A selective 5-HT_2C serotonin receptor inhibitor with lesser affinity for 5-HT_2BR. Often used in conjunction with ketanserin to distinguish 5-HT_2AR and 5-HT_2CR activity. SB206553 has highest affinity for 5-HT_2CR (K_i = 3.2nM) and less for 5-HT_2BR (K_i = 5.5 nM) and 5-HT_2AR (K_i = 2,300 nM).

Biochem./physiol. Wirkung

Primary Target
5-HT_2C

Secondary Target
5-HT_2B

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable