400015

Caspase-1 Inhibitor IV

The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Caspase-1 Inhibitor IV, ICE Inhibitor IV, Ac-YVAD-AOM
• Empirische Formel (Hill-System): C₃₃H₄₂N₄O₁₀
• CAS-Nummer: 154674-81-4
• Molekulargewicht: 654.71
• MDL-Nummer: MFCD00798794
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥96% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated
• Farbe: white
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)COC(=O)c2c(cccc2C)C)C(=O)[C@@H](NC(=O)C)Cc1ccc(cc1)O
• InChI: 1S/C33H42N4O10/c1-17(2)29(37-31(44)25(35-21(6)38)14-22-10-12-23(39)13-11-22)32(45)34-20(5)30(43)36-24(15-27(41)42)26(40)16-47-33(46)28-18(3)8-7-9-19(28)4/h7-13,17,20,24-25,29,39H,14-16H2,1-6H3,(H,34,45)(H,35,38)(H,36,43)(H,37,44)(H,41,42)/t20-,24-,25-,29-

Beschreibung

Allgemeine Beschreibung

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
caspase-1

Product does not compete with ATP.

Reversible: no

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)

Rekonstituierung

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable